2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N7259
    (+)-Isomenthone 1196-31-2 ≥98.0%
    (+)-Isomenthone is an isomenthone isolated from Ziziphora clinopodioides Lam.. (+)-Isomenthone is an isomer of L-Menthone.
    (+)-Isomenthone
  • HY-N7263
    Galanthamine N-Oxide 134332-50-6 99.90%
    Galanthamine N-Oxide is an alkaloid obtained from the bulbs of Zephyranthes concolor. Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC50 of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes.
    Galanthamine N-Oxide
  • HY-N7421
    Smilagenin acetate 4947-75-5 99.68%
    Smilagenin acetate is a sapogenin derivative extracted from patent US20030004147A1. Smilagenin acetate increases the expression of acetylcholine m2 receptors and can be used for the research of dementia.
    Smilagenin acetate
  • HY-N7509
    2,3-Dihydroxy-4-methoxyacetophenone 708-53-2 99.63%
    2,3-Dihydroxy-4-methoxyacetophenone is a neuroprotective compound from Cynenchum paniculatum. 2,3-Dihydroxy-4-methoxyacetophenone improves cognitive function and may has the potential for the treatment of Alzheimer's disease research.
    2,3-Dihydroxy-4-methoxyacetophenone
  • HY-N7514
    Strictosidinic acid 150148-81-5
    Strictosidinic acid, an orally active glycoside indole monoterpene alkaloid isolated from Psychotria myriantha leaves, inhibits precursor enzymes of 5-HT biosynthesis and reduces the 5-HT levels. Strictosidinic acid has peripheral analgesic and antipyretic activities in mice.
    Strictosidinic acid
  • HY-N7763
    Casuarictin 79786-00-8 98.62%
    Casuarictin is a potent and competitive α-glucosidase inhibitor with an IC50 of 0.21 μg/mL. Casuarictin is a presenilin stabilization factor like protein (PSFL) protein inhibitor. Casuarictin can be used for Alzheimer's disease research.
    Casuarictin
  • HY-N8175
    3'-O-Methylbatatasin III 101330-69-2 99.68%
    3'-O-Methylbatatasin III shows spasmolytic activity.
    3'-O-Methylbatatasin III
  • HY-N8284
    Tomentosin 33649-15-9 98.95%
    Tomentosin is an orally active natural sesquiterpenoid lactone. Tomentosin exhibits multiple activities such as anti-tumor, anti-fungal, anti-inflammatory, anti-oxidant and neuroprotective effects. Tomentosin can inhibit tumor cell proliferation, migration and invasion, and induce apoptosis. Tomentosin can be used in the research of tumors, inflammation and nervous system diseases.
    Tomentosin
  • HY-N8487
    7-Methoxyflavone 22395-22-8 ≥98.0%
    7-Methoxyflavone is a flavonoid compound that can be isolated from Zornia brasiliensis. 7-Methoxyflavone can bind to human serum albumin and is an aromatase inhibitor. 7-Methoxyflavone has peripheral analgesic and certain antitumor activities. 7-Methoxyflavone is effective against chemical pain but has no significant effect on thermal pain.
    7-Methoxyflavone
  • HY-N8804
    Shatavarin IV 84633-34-1 98%
    Shatavarin IV is a steroidal saponin, that can be isolated from the roots of Asparagus racemosus (Liliaceae). Shatavarin IV shows anticancer activity. Shatavarin IV elicits lifespan extension and alleviates Parkinsonism in Caenorhabditis elegans.
    Shatavarin IV
  • HY-N8829
    (-)-Myrtenol 19894-97-4 98%
    (-)-Myrtenol is the enantiomer of Myrtenol. (-)-Myrtenol has anti-anxiety effect. (-)-Myrtenol has the characteristics of gastric cell protection.
    (-)-Myrtenol
  • HY-N9241
    3-Hydroxy-7-methoxyflavone 7478-60-6 98.53%
    3-Hydroxy-7-methoxyflavone (compound 1) is a flavonoid. 3-Hydroxy-7-methoxyflavone is isolated from natural Salvia elegans. 3-Hydroxy-7-methoxyflavone has anti-anxiety effect .
    3-Hydroxy-7-methoxyflavone
  • HY-N9372
    Crocetin β-D-glucopyranoside 58050-17-2 98.59%
    Crocetin β-D-glucopyranoside is an active part of saffron pigments extracted from patent CN 105935363 A.
    Crocetin β-D-glucopyranoside
  • HY-N9404
    6-Benzoylheteratisine 99759-48-5 99.66%
    6-Benzoylheteratisine is an Aconitum alkaloid with potential neuroprotective activity. 6-Benzoylheteratisine can antagonize tetrodotoxin, inhibit the increase of [Na+]i, [Ca2+]i and glutamate release, and block sodium channels. 6-Benzoylheteratisine has an inhibitory effect on the neuronal activity underlying epileptiform burst discharge.
    6-Benzoylheteratisine
  • HY-N9447
    Norbergenin 79595-97-4 98.31%
    Norbergenin, the O-demethyl derivative of bergenin, shows moderate antioxidant activity (IC50 13 μM in DPPH radical scavenging; 32 μM in superoxide anion scavenging).
    Norbergenin
  • HY-N9502
    Linalool oxide 60047-17-8 ≥98.0%
    Linalool oxide is a secondary metabolite in elongating wheat plants with antinociceptive and anticonvulsant effects. Linalool oxide shows anxiolytic activity.
    Linalool oxide
  • HY-N9506
    Anisatin 5230-87-5 ≥99.0%
    Anisatin, a pure toxic substance isolated from the seeds of a Japanese plant (Illicium anisatum) acts as a picrotoxin-like, non-competitive GABA antagonist. Anisatin suppresses GABA-induced currents in a concentration-dependent manner with an EC50 of ~1.10 μM.
    Anisatin
  • HY-N9690
    Longistyline A 64095-60-9 98%
    Longistyline A (Longistylin A) is a natural stilbene, it can be isolated from leaves of Cajanus cajan. Longistyline A shows antimicrobial activity against MRSA with an MIC value of 1.56 μg/mL. Longistyline A shows neuroprotective effects, it can be used for the research of infection and nerve diseases.
    Longistyline A
  • HY-P0181
    Microtubule-associated protein tau (26-44) 98.10%
    Microtubule-associated protein tau (26-44) is a synthetic peptide chain with an amine group attached to glutamine and an carboxyl group attached to lysine.
    Microtubule-associated protein tau (26-44)
  • HY-P0204
    Endothelin-3, human, mouse, rabbit, rat 117399-93-6 98%
    Endothelin-3, human, mouse, rabbit, rat is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.
    Endothelin-3, human, mouse, rabbit, rat
Cat. No. Product Name / Synonyms Application Reactivity